This is supported by high levels of reactive oxygen species (ROS) or nitric oxide (NO), which can irreversibly impact RyR1 subunits as a consequence of oxidation [ 81].
It appears that SNP binds to glucose receptors irreversibly [ 33], impacting the glycolytic pathway and generation of energy.
In addition, our data indicate that shoreline modifications have led to cumulative impacts that have irreversibly modified Great Lakes nearshore coastal habitats and the processes that create and maintain them.
The mechanisms of cell death after TBI and SCI include initial necrosis of irreversibly damaged cells in the impact area, followed by delayed secondary cell death in the neighboring penumbral regions (3, 54).
The mangrove stands, which reestablished at KLB 1 after EWE I, were irreversibly destroyed by a major wave impact (EWE II) overtopping the barrier.
It warns that current expectations will lead to the profession being "irreversibly damaged – which will have a devastating impact upon our children's life chances".
From the results obtained, the contribution of fibre breakage and matrix damage to the irreversibly absorbed energy is comparable at low impact energies; with increasing initial energy levels, delamination becomes predominant in determining energy dissipation.
The "singularity," as defined in his book "The Singularity Is Near," is "a future period during which the pace of technological change will be so rapid, its impact so deep, that human life will be irreversibly transformed".
The singularity, writes Kurzweil, is "a future period during which the pace of technological change will be so rapid, its impact so deep, that human life will be irreversibly transformed".
However, such methods might have the greatest impact at the strategic level where substantial resources are irreversibly allocated.
