In arguing for clarity, simplicity and hope, Wells undervalued his readers but also failed to see how radically and irreversibly science was changing the culture of his own time.
Two zones of excavation-affected rock have been shown to exist from studies at the URL; (1) a zone of irreversibly damaged rock surrounding the excavation, which may include failed zones, inner and outer damage zones and (2) a zone of excavation disturbance where the in situ stresses are influence by the excavation no damage is measurable.
Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation.
It is more difficult to explain why Pdimax did not improve in about half of our patients, resulting in failed weaning, but it might be that the diaphragm fibers were irreversibly damaged by the more prolonged ventilation (Table 1).
Both a P2Y1R selective antagonist N-methyl-2′-deoxyadenosine-3′,5′-bisphosphate (37, MRS2179) and a P2Y6R selective irreversibly binding antagonist N, N″-1,4-butanediyl bis[ N′- 3-isothiocyanatophenyl)]thiourea (38, MRS 2578) failed at 10 μM to preveN′- 3-isothiocyanatophenyl
In recent years, as studies involving people who already have Alzheimer's have failed, researchers increasingly have called for studies in those who do not yet have the disease, arguing that the time to intervene is before the brain is irreversibly damaged.
A very "my parents bought me a suit for a job interview I failed eight months ago and now I'm trying to get one last wear out of it before my waist size goes up irreversibly" kind of costume, isn't it.
The commanders' approach failed to acknowledge the real lesson of Quetta: decades of Pakistani military and intelligence support underwritten by funding from Saudi Arabia for sectarian and ultra-conservative groups and religious schools in Pakistan that has divided the country almost irreversibly.
Building on green belt land around towns and cities will "irreversibly damage the countryside" yet fail to deliver the Government's hoped-for economic growth, the former poet laureate Sir Andrew Motion warns today, as ministers face charges that they are ignoring the needs of Britain's rural communities.
"We are now on the edge of seeing the entire international climate regime system disintegrate and fail more or less irreversibly". And with it, many would argue, would go any hope of restraining the global average temperature rise within the 2C limit that has become such a commonly-cited touchstone of "maximum safe" warming.
