Lineage fate mapping using bacterial artificial chromosome (BAC) transgenic mice in which cre-recombinase is controlled by RORγt regulatory elements irreversibly labels cells developing through the conventional CD4+8+ TCRαβ, but not the DN TCRγδ, pathway.
Indeed, as countries become middle class, they tend to become irreversibly diverse and democratic, developing the bedrock for democratic governance, including consensual politics and respect for individual and minority rights.
Improper clearance of apoptotic debris through their opsonization by maternal antibodies and subsequent removal by macrophages may lead to a sustained inflammation in the fetal heart, eventually damaging the developing organ irreversibly.
Morpholino-mediated knockdown of dnd in several teleost species leads to removal of protection of key PGC-specific transcripts from miR-430-guided suppression, and consequently PGC development is arrested, germline lineage is lost, and the developing individuals are irreversibly sterile (Weidinger et al. 2003; Fujimoto et al. 2010).
Even the equilibrium microstructure develops irreversibly with changing temperature, i.e. the microstructure evolution paths for the direct and the reverse transformations are different.
Responses developed irreversibly and were slower than for downstream Y1 receptor YFP internalization, a consequence of delayed maturation and stability of complemented YFP.
As a neurotoxicant, lead is especially harmful to the developing brain, and early exposures can irreversibly impair children's cognitive and behavioral development.
For Brugia spp., injection of females to transform developing embryos is difficult and can irreversibly damage the animal (Higazi et al. 2002), while biolistic transformation of embryos renders them developmentally incompetent (Shu et al. 2003).
The real number of medicines proven to be teratogenic – that is an agent that irreversibly alters growth, structure or function of the developing embryo or fetus [ 42] – remains fewer than 30 [ 43].
Ultimate goals include developing a once-daily combination that avoids irreversibly damaging the immune system and delays disease progression.
