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S1P can irreversibly be degraded into hexadecenal and ethanolamine phosphate by sphingosine 1-phosphate lyase (SPL) [ 20].
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Additional small molecule dual EGFR-Her2 inhibitors which bind irreversibly are in earlier stages of clinical development.
The idea of "peak oil" - the year when global annual production of oil reaches its highest point and thereafter declines irreversibly - is now central to the debate about oil as a world energy source.
However, graphene tends to agglomerate irreversibly and is difficult to well re-dispersed in organic solvents and polymer matrix.
Skeletal muscles degenerate progressively and irreversibly and are replaced by fibrotic tissues (1).
At the time, newsprint appeared to be irreversibly fading before a multimedia future.
Both the capacity for consciousness and the capacity to breathe will be irreversibly lost.
The process permits the cells to be irreversibly deformed and is accompanied by the entry of water and the synthesis of new cell-wall material.
Biological materials, however, can be irreversibly damaged during these treatments.
If you change a computer or reinstall Windows your Skype history will be irreversibly lost.
During vaginal delivery, the pelvic floor can be irreversibly traumatised, resulting in pubovisceral muscle avulsions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com