Sentence examples for irreversible status from inspiring English sources

On the other hand, in shRNAHigh cells, a greater loss of NDUFS3 led to a, plausibly, irreversible status of mitochondrial dysfunction where sustained ROS imbalance was just not sufficient to exacerbate the aerobic glycolysis phenotype but also necessary to sustain this phenotype even in the presence of exogenous antioxidant mimetics.

Moreover, in contrast to physiologic hypertrophy, pathological cardiac remodelling is characterized by an irreversible phenotype status [ 11, 33].

This supports a critical role of ING1 protein in the induction of cellular senescence, whereas it remains to be shown whether ING1 is required for maintenance of the irreversible cellular senescence status.

Although fibrosis is usually an irreversible pathological condition, targeting underlying molecular effectors may reverse an active status of the fibrotic process, and subsequently inhibit fibrosis.

The move to academy status is irreversible; these are important questions.

Thus, targeting CRABP2 function prevents RARα function and affects, in a negative and irreversible fashion, the transcriptional status of RA-responsive genes downstream of RARα.

While most of risk factors for infection such as immunoparesis, comorbidities, and performance status are irreversible, hyperglycemia induced by steroid could be reversible.

So for many older patients, hospitalization is followed by an often irreversible decline in functional status and quality of life [ 8].

The irreversible component correlates with radiological status, mainly cartilage destruction and subluxation, and worsens with time.

Effective antioxidant activity is necessary to buffer fluctuations in the cellular redox status and avoid irreversible oxidation of integral cellular macromolecules such as proteins, lipids and DNA.

Two of the patients (#1 and #4) died due to irreversible deterioration of their clinical status, and the other two (#2 and #3) fully recovered.