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Mucoid conversion dramatically increases the resistance of the bacteria to pulmonary clearance mechanisms, and marks the transition to an irreversible state of the infection [12], [13].
In Pseudomonas aeruginosa, conversion to the mucoid phenotype marks the onset of an irreversible state of the infection in Cystic Fibrosis (CF) patients.
In fact, the emergence of the mucoid phenotype in the CF lung marks the onset of an irreversible state of the infection and poor prognosis for the patient [12].
The Xi provides a clear example of the stable and irreversible state of gene repression during cell differentiation.
If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence.
The centrosome has been implicated in cell-cycle arrest, but its involvement in the irreversible state of senescence remains less clear.
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For this type of inhibition, the cessation of product formation at long time points (the plateau in Figure 1) implies a quasi-irreversible state of inhibition of the enzyme, at least under the pH 9.5 conditions of the assay.
When we estimated the raw number of irreversible states on the phylogeny, we only considered those irreversible states that had a posterior probability on the placental tree of >0.95.
For each gene, we obtained a phylogeny spanning the vertebrate clade and identified irreversible states on nodes before the evolution of placental mammals.
We thus tested whether or not 51 genes with at least one identified irreversible state are representative of the rate of irreversibility of the entire set.
Thus, incorporation of mH2A1 correlates with a switch from a reversible state (Xi(Epi), no mH2A1) to an irreversible state (Xi(diff), mH2A1 positive) of the Xi.
More suggestions(16)
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