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A more complex rationalisation would point to the problem of clinical inertia: insulin in the real world is given late, after chronic exposure to high glucose levels, thus marking subjects with poor irreversible legacy.
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Now, with a quieter job in finance, she lives with the legacy of irreversible damage to her inner ear.
Political analysts and even Mr. Ma's allies in the governing Nationalist Party worry that Typhoon Morakot could become his "Katrina moment," a blot on his legacy and perhaps an irreversible turning point just 15 months into his administration.
Continuing carbon dioxide emissions in the future means further irreversible effects on the planet, with attendant long legacies for choices made by contemporary society (Ramanathan and Feng 2008).
Yet, as I await the releases of his albums in June, I imagine that West's admiration of Trump, however much he wants to divorce it from the President's appalling xenophobia, will warp his artistic legacy in a way that could prove irreversible.
But, in this case, the epigenetic modification could be inherited from either the mother or the father.Intriguingly, though this silent legacy could persist for at least three generations, it was not an irreversible alteration.
Irreversible decline?
Irreversible brain damage is irreversible.
It is irreversible.
Is the damage irreversible?
"The trend is irreversible".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com