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The Roblès' rebel, however, knows how to savour his short-lived happiness before irreversible fate seals him in.
Strong as Wink may be, we fear that the non-gender conforming youngster may fall prey to the same irreversible fate that many other LGBTQA kids have.
Thank you for sending your work entitled "Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module" for consideration at eLife.
According to the common stem cell paradigm this balance can be explained assuming a strict differentiation hierarchy and irreversible fate decisions [ 1, 2].
Mitotic catastrophe is an important oncosuppressive mechanism that senses mitotic failure and responds by driving the cell to an irreversible fate of death or senescence.
Originally used as a denomination for 'death during mitosis', mitotic catastrophe reached a tentative consensus, defined as a mechanism that senses mitotic failure resulting in an irreversible fate, such as apoptosis, necrosis or senescence.
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This is normally thought to involve the establishment of divergent chromatin patterns that culminate in cells with distinct and what were previously thought to be irreversible fates.
Xenopus oocyte maturation is an example of an all-or-none, irreversible cell fate induction process.
Higher eukaryotes can thus control low rates of near irreversible cell fate decisions through a balancing act between noise and ultra-high feedback connectivity2,3,4.
Higher eukaryotes can thus control low rates of near irreversible cell fate decisions through a balancing act between noise and ultrahigh feedback connectivity.
This novel property of breast epithelial cells is neither classical senescence, which is defined as an irreversible cell fate, nor the transient senescent arrest described for normal hMECs from which rare variant cells evolve.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com