Sentence examples for irreversible expression from inspiring English sources

In Dbx1Cre R26YFP embryos, Cre-mediated recombination occurs at the ROSA26 locus in every cell expressing dbx1, leading to a permanent and irreversible expression of YFP.

Most significantly, a number of genes were identified that exhibited irreversible expression changes upon smoking cessation.

Protein coding genes deregulated in response to active smoking display either reversible or irreversible expression upon smoking cessation [ 23– 25].

Only 4-day exposure followed by 2 days washout (medium pulse) resulted in sufficient irreversible expression alterations to correctly classify the test compounds.

We investigated this phenomenon with respect to miRNA expression in FS non-malignant tissue (FSN), and identified two miRNAs exhibiting patterns consistent with reversible expression and 15 with irreversible expression in FSN (Additional file 4).

In a study by Spira et al [ 11], a gene with irreversible expression was defined as a gene whose expression was different between current and never smokers, but also different between former and never smokers.

It is interesting to note that MUC5AC appears in both the lists of statistically reversible and irreversible gene expression changes suggesting that expression of this gene exhibits distinct states of expression among current, former and never smokers.

Here, we focus on identifying both reversible and irreversible gene expression changes and specifically consider these expression changes in the context of airway mucosal response, and susceptibility to cancer development.

This presents a problem, since the authors' hypothesis of "reversible" and "irreversible" gene expression change would lead one to expect that never and current smokers would define the limits of expression, with former smokers falling somewhere within this continuum.

Indeed, this seems to be the most natural way of identifying "reversible" and "irreversible" gene expression differences.

In physiological kidney repair, reversible fibroblast activation is associated with reversible RASAL1 suppression without RASAL1 hypermethylation; whereas in pathological kidney fibrosis, perpetual fibroblast activation is associated with irreversible RASAL1 expression due to RASAL1 promoter hypermethylation (Bechtel et al., 2010).