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However, as they will not degrade in the environment, there is a permanent and irreversible exposure of organisms.
And "if you eat plants highly contaminated with short-chain PFASs on a regular basis, you will have a high irreversible exposure," says Ian Cousins, an environmental scientist at Stockholm University, who is one of 14 lead authors of the consensus statement.
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Many of these changes were irreversible after exposure to MeHg was discontinued.
The results provide evidence that a fraction of Fe(IV) sites, as monitored in situ, undergo a gradual and irreversible decrease upon exposure of the material to an alkaline solution.
In our study, accumulated PpIX within the glioma cells may have caused irreversible photodamage by exposure to a specific wavelength.
In addition, experimental, clinical and epidemiologic evidence supports the notion that neurotoxicity may be much more severe and possibly irreversible when the exposure occurs during early development.
The heart block of neonatal lupus is not only progressive (second to third degree) but also characteristically irreversible, despite brief exposure to autoantibodies and a limited period of inflammation.
Issues discussed here include the hypothesis of greater sensitivity of embryos/fetuses to endocrine disruptors, irreversible consequences of exposure before maturation of homeostatic systems and during periods of genetic imprinting, and quantitative information related to the shape of the dose-response curve for specific developmental phenomena.
Placebo control may be permissible also in connection with disorders that already have a known effective treatment, when there are compelling and scientifically sound methodological reasons for its use and the participants in the study will not face additional risks of serious or irreversible harm from exposure to placebo [ 6, 7].
As described above, many THRA defects in RTHα abrogate hormone binding to receptor, such that dominant negative inhibition exerted by mutant TRα1 in vitro or in patient's cells studied ex vivo is irreversible, even following exposure to high T3 levels.
For small exposures, the sensor is fully recoverable; however for very large exposures, irreversible chemical changes in the polymeric sensing material occur.
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CEO of Professional Science Editing for Scientists @ prosciediting.com