Furthermore, beside those cells that have retained the ability to revert back into the Nanog-high state, the population of Nanog-low cells might also contain cells that have already initiated further differentiation including the irreversible down-regulation of Nanog and other relevant pluripotency genes.
An unexpected observation was that DNMT1 depletion leads not only to gene activation but also to irreversible down-regulation of a defined set of mitosis/division-related genes.
This means that the liver has an idiosyncratic reaction that causes it to go into irreversible shut down.
This, in turn, launches an irreversible trickle down effect, and before we all know it, we're living in a post-apocalyptic wasteland with no way to move about and wishing, begging, for the pleasure of watching paint dry.
In a piece of achingly beautiful writing, this observation may bypass the typical outsider but as an oncologist, it struck me as the essence of what it takes to die well – the concession that all the well-intentioned therapy in the world can no longer prevent one from going down the irreversible trajectory of death.
If the wave of revolt sweeping across the postcolonial borders of the Arab world looks as irreversible as the one that brought down the Soviet empire, revolution does not fit the bill either.
An irreversible mechanism of CDK down-regulation is destruction of cyclin subunits [ 2, 3].
Last week the government moved to rebut accusations that the deal was being driven by the interests of big transnational companies which variously want to deregulate markets, make NHS privatisation irreversible, and water down regulations on food standards and banking.
The large irreversible capacity may be put down to a solid electrolyte interface (SEI) film is formed on the electrode surface.
But there was no doubt that the central decision, to clamp down on bonuses, was irreversible.
