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I propose an alternative epigenetic landscape that has numerous valleys and ridges right from the start, with the process of cell-fate commitment corresponding to the irreversible disappearance of some of these valleys and ridges, via cell-fate induction, complemented by the creation of new valleys and ridges through processes like cell cell competition.
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But, in the majority of the cases, the vernacular architecture of river banks has been subjected to a rapid and significant disappearance, with the irreversible loss of a unique cultural, architectural and environmental legacy, weakening the sense of place, the identity of local communities with their territories and the cultural heritage of the countries.
The insecticide phosphorylates or carbamoylates the active site serine of one enzyme molecule and the inhibition can be considered as irreversible during the first 30 min. Disappearance of free enzyme ([E]) follows second-order kinetics.
Order-of-addition experiments indicated that TMD egress from the cytosolic vestibule (operationally defined by the disappearance of TMD/Sec61α crosslinks) becomes irreversible once the nascent chain has progressed from 106- to 126-mers.
Unrestricted population growth is leading to the disappearance of nonrenewables and to an irreversible accumulation of solid, liquid and gaseous waste from industry, agriculture, humans and animals.
The results achieved underscore the urgency of adopting air quality thresholds that are compatible with the preservation of the cultural heritage, in order to avoid irreversible damage, escalating restoration costs, and the gradual disappearance of our monuments under a cloak of blackness.
Besides degradation, disappearance of tylosin in manure is attributed to irreversible sorption, i.e. the formation of non-extractable bound residues [21].
Figure 3 shows that the tumour cells of breast cancer treated with HIFU were very abnormal, with the appearance of irreversible cell death, as demonstrated by pyknotic nuclei, nuclear disruption, and disappearance.
The disappearance of the plateau region may be associated with a decrease in the irreversible reaction that involves the evolution of oxygen during the initial charging process.
"This [agreement on disappearances] is a further sign that the negotiations are entering an irreversible phase, if not the actual 'home stretch'," Adam Isacson, a Colombia expert at the Washington Office on Latin America, told VICE News.
"The disappearance of a person leaves those who loved him with a sensation of permanent and irreversible anguish," she said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com