Muscle biopsies taken in the neonatal period are essentially identical to those of children with irreversible and fatal COX deficiency.
This implies that even a transient folate deficiency is sufficient to disrupt genome integrity and enhance tumorigenicity, as DNA damage that was generated under conditions of folate deficiency is irreversible and thus cannot be recovered subsequent to later folate supplementation.
AMD, the main cause of irreversible central vision function deficiency in developed countries among people over 50 [ 4, 6], includes geographic atrophy, choroidal neovascularization, and detachment of RPE [ 11– 13].
Moreover, we showed that even a mild transient folate deficiency is sufficient to disrupt genome integrity and enhance tumorigenicity, since DNA damage that had been generated under conditions of folate deficiency is irreversible and thus cannot be recovered after later folate supplementation.
Importantly, the changes of oxylipin levels are reversed by short-term K re-supply (as previously also shown for changes in transcripts, tissue K contents and most primary metabolites [ 2, 6], Table 1) proving that they are not secondary effects of leaf senescence or other irreversible symptoms of K-deficiency.
Stunting is the irreversible outcome of chronic nutritional deficiency during the first thousand days of a child's life.
Stunting is the irreversible outcome of chronic nutritional deficiency during the first 1,000 days of a child's life.
Stunting is the irreversible outcome of chronic nutritional deficiency during the first thousand days of a child's life, from conception through pregnancy to the age of two.
Stunting during the first 1,000 days of life is the irreversible outcome of chronic nutritional deficiency and the damage it causes to a child's development is permanent.
Stunting, or being too short for one's age, is an irreversible outcome of chronic nutritional deficiency during the first 1,000 days of a child's life.
