We recognize the urgent need to act now to avoid irreversible costs to our global community's economic prosperity and public health.
They are thus always vulnerable to political risk that could block their completion years after the initial investments were made with heavy and irreversible costs.
Last year, the financial industry barraged the regulator with thousands of comment letters that complained about this one rule's "immediate, irreversible costs," but it was eventually finalized in October.
Ending DACA would also have "profound and irreversible" social costs, Judge Garaufis said, as hundreds of thousands of recipients are separated from their families.
Spending more on housing often means people incurring more mortgage debt, working longer hours, or commuting a longer distance, while building more homes has significant and irreversible environmental costs.
With over a million homes destroyed, and cultural heritage sites facing irreversible damage, the cost of demolition and the removal of rubble alone could exceed a billion dollars.
And even if the law is repealed after the next election, the economic pressure to care differently for more people at lower cost is irreversible.
The global citizen's call for a five-year freeze on release of GMOs into our agriculture and food systems is a necessary pause that should induce responsibility, sanity and safety in the insane rush to sell GMOs at any cost, including irreversible risks to biodiversity and human health.
The sensitivity analyses reported here are those that either (a) had a significant impact on the incremental cost-effectiveness ratio, or (b) related to parameters for which reliable published estimates were not available (e.g. QALYs per year of life lived with CF symptoms or severe irreversible symptoms, and the cost of pre-diagnosis care for those diagnosed symptomatically).
And what of the downstream public health costs and irreversible loss of biodiversity?
