Namely, the events we detected complied the detection criteria of Massimini et al. [21] on at least one site of detection: this allows for the detection of SSOs irrespectively from the wave amplitude evolution during the event propagation.
Conversely, there was no difference in terms of DFS in the other subgroups of patients according to the detection of CK-19 CTCs before and after adjuvant chemotherapy, irrespectively of the administered chemotherapy regimen (data not shown).
In a similar study, Dawood et al (2008) confirmed that the detection of <5 CTCs/7.5 ml of blood at baseline in patients with newly diagnosed MBC was associated with a significantly better OS compared with those with ⩾5 CTCs/7.5 ml of blood, irrespectively of the hormone receptor and HER-2/neu status, site of first metastasis or whether the patient had recurrent or de novo metastatic disease.
Moreover, for the first time in history, the IPR regime has become increasingly uniform at international level by means of the TRIPS agreement, irrespectively of the degrees of development of the various countries.
In general, closing and connecting to the outside world these miniature labs remain a challenge irrespectively of the type of application pursued.
Thus, in the particular case of fluorescent objects, only the intensities of the SIPs are summed, irrespectively of the type of their excitation light.
It is important to note, that a process evolution function maps the recorded events of a process to a process state irrespectively of the number of recorded events.
