A significant challenge for this technology is to develop assay conditions where an even hybridisation of targets to attached oligonucleotides is achieved, irrespective of the base composition of the sequence (the GC AT ratio).
This demonstrates that the two reaction pathways can compete, however use of Et-, i Pr- or t Bu-substituted γ-hydroxysulfones 5 led exclusively to the sultones 4 b, d, e in >90 % yield in each case irrespective of the base used.
ROC analyses use the association between sensitivity and specificity to derive an area under the curve (AUC), which indicates how well a measure distinguishes between case positives (i.e., OCD group) and case negatives (i.e., psychiatric controls or population controls) irrespective of the base rate.
However, interactions between conserved motifs I, II, and VI and nucleotide phosphate moieties are sufficient to promote duplex unwinding at lower efficiency irrespective of the nucleotide base.
In general, and irrespective of acid-base balance, fatiguing exercise induces ion concentration changes between the intracellular, interstitial and extracellular compartments.
As is evident from the classification results, the pitch-harmonicity measure allows for more accurate identification of musical instruments for all values of τ n, irrespective of pruning based on acceptable note size.
A previous publication including a subset of this study population, showed an overall concordance of 80%% between TMAs and whole sections for IHC assessment of ER, PR, and HER2, and notably the prognostic value of these markers was similar irrespective of assessment based on TMA or whole sections [ 36].
Among two-year-old children, irrespective of race, based on our analyses we would predict an average difference of three-quarters of a BMI unit between children with high levels of externalizing behavior and children with low levels of externalizing behavior.
Mutant F64A was only able to catalyze minimal insertion of either GTP or CTP irrespective of the templating base used (dC; Figure 5A), supporting a more general role in orienting any base selected as template.
The public health workforce is diverse and includes all those whose prime responsibility is the provision of core public health (non-personal) activities, irrespective of their organizational base.
The public health workforce is diverse and includes all those whose prime responsibility is the provision of core public health activities, irrespective of their organizational base.
