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The phrase "irreplaceable significance" is correct and usable in written English.
It can be used to describe something that holds a unique and essential importance that cannot be substituted or replaced. Example: "The contributions of the late scientist have an irreplaceable significance in the field of medicine."
Similar(54)
It is true that studies on acupoints should be performed in humans, but we believe that studies conducted with animals also have irreplaceable significance.
It is of irreplaceable strategic significance to Pyongyang," says the daily.
Do you want to see the historical significance of both of these irreplaceable battlefields marred forever by more pavement, more traffic and more development that a Wal-Mart Supercenter will bring in its wake?
It's literally irreplaceable.
Roger is irreplaceable.
Few products are irreplaceable.
Gifted irreplaceable educator.
No one is irreplaceable".
That thunk is irreplaceable.
This is irreplaceable capital".
"These are irreplaceable objects".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com