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Thus irremediable mischief would result.
Conflating the standard video warning with psychedelic, psychological posturing ("are you experienced?") invokes a momentary cringe, but its effects aren't irremediable.
Drug companies face an excruciating dilemma, where doing the right thing may result in doing themselves irremediable harm.
Instead, the consequence of overshooting a goal should simply be an irremediable overproduction of terminal cells.
The effect of this interference with Microsoft's development of new products during the pendency of an appeal will be irremediable even if Microsoft prevails.
Is our defeat final and irremediable?
"Evil has an irremediable stubbornness about it.
Disconsolate, bitter, irremediable things became him.
"They have their fallouts, but nothing is irremediable.
The consequent destruction of natural values is irremediable.
"The effects may be less dramatic in the short term than the destruction that could be wrought by nuclear explosions, but over the next three to four decades, climate change could cause irremediable harm to the habitats upon which human societies depend for survival," it added.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com