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In this study only 5% of trials in which patient reported outcomes were ranked as irrelevant reported such outcomes, therefore dismissing any concerns for substantial misuse.
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Titles and abstracts were examined by one investigator (PIB) and obviously irrelevant reports removed.
Two review authors (W-WS, Y-TW) will separately examine titles and abstracts to exclude the obviously irrelevant reports.
The title and abstract of each study identified in the search were scanned to exclude any clearly irrelevant reports.
The titles, abstracts and descriptor terms of all material downloaded from the electronic searches were read and irrelevant reports were discarded.
19 27–33 The resulting inventory consisted of 31 quality criteria within five domains: external validity, presentation of outcomes, minimisation of irrelevant variance, reporting and analysis, and other aspects (see online supplementary appendix 2).
Busner et al. [ 16] found that the CGI ratings of the clinicians are affected by indication-irrelevant adverse events reported by the patient.
The marR-K62R mutation found in some of the HR isolates in this study was previously reported as irrelevant to the loss of MarR function.
Interestingly, most studies on the efficacy of daily routine CXR did not attempt to discriminate between clinically relevant and irrelevant findings, and simply reported on all abnormalities [ 12].
Norredam et al compared patients of Danish origin with immigrants, and found that immigrants have more irrelevant EHS claims and reported going to the EHS because they could not contact a general practitioner [ 26].
Thirdly, comparisons with other studies are limited: 1 Different questionnaires cover different aspects of QoL making comparisons irrelevant, 2 Previous studies have reported on relatively old samples from the 1970s and 1980s and 3 most studies have tended to focus on extremely preterm children, who may have experienced more difficulties overall than our sample.
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CEO of Professional Science Editing for Scientists @ prosciediting.com