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Negative controls for fibroblast transfection and cellular reaction included plasmids lacking a viable tsRNA promoter sequence and empty pMU2 plasmid demonstrated therapeutically irrelevant increases in gem numbers (Figure 6A).
Recently, Hy's law was modified to limit 'clinically irrelevant' increases of ALT, by increasing the threshold to five-fold and including ALP to cover the hepatobiliary component of DILI (reviewed in [ 2]).
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It is true there will be many more people in the very, very tiny minority who live to 100, a "striking" but irrelevant increase.
The concurrent and parallel (but arguably irrelevant) increase in sebocyte and sebum production responds to the same chain of stimuli.
DARC-/ on the other hand displayed a significant protection from ARF, exhibiting only a small, clinically irrelevant increase in Crea over 24 hours (Fig. 1).
At doses of 2 mg and 10 mg prucalopride, a small and clinically irrelevant increase in HR was observed, but there were no significant differences between prucalopride and placebo in ECG morphological changes or arrhythmias.
Pooled estimates after short term follow-up showed a statistically significant but clinically irrelevant increase in postoperative flexion with high flexion replacement (3.7° (95% confidence interval 2.0 to 5.4) in 26 non-randomised studies, and 1.6° (0.3 to 2.8) in 16 randomised studies) (fig 2).
Some may argue that absolute rates of events were low and clinically irrelevant, despite increases in rate ratios.
We observed that clearly when the number of irrelevant features increased, the noisier data made the learning problem more difficult, and SE y) and SE(w) increased in both of the settings.
The tendency to use various finishes and functionally irrelevant elements increased under his watch.
Feature selection, as a preprocessing step to machine learning, has been very effective in reducing dimensionality, removing irrelevant data, increasing learning accuracy, and improving result comprehensibility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com