Similar situation may occur for candidate genes identified by mass spectrometry, considering their related (or irrelevant) expression and function.
For the biclustering, the preprocessing step aims to remove irrelevant expression values of the data matrix M that do not contribute in obtaining pertinent results.
To help identify those genes that are relevant from those that have inconsistent or irrelevant expression patterns we make use of a large mRNA expression data set of ER+ (785 samples) and ER- (438 samples) tumours over a common set of 6265 genes, obtained by merging seven different cohorts together ("Set1") [ 2, 24, 40- 44].
It is also, I should hardly need to point out, irrelevant, the expression of a tired trope.
Thus, promoter-mediated noise seems irrelevant of expression noise associated with weak silencing.
In order to weed out virulence-irrelevant responses, expression profiles of isogenic avirulent strains lacking essential virulence regulators [ 21, 22] were compared in parallel.
It is simply irrelevant whether an expression is required for a particular purpose: its logicality rests on features that it has independently of any use to which we might put it.
The decreased excitabilities in PCs and INs do not affect the performance of the learned generation of the CR, because the depressed PCs and INs simply do not generate the long-time scale potentials at the CS, and are thus irrelevant to the expression of the CR. Figure 7A shows PCs having a variety of responses, often with multiple peaks similar to the patterns in vivo [43].
We did not explain this discrepancy, but we suggested that venous invasion may be an independent prognostic factor irrelevant to survivin expression.
Although "FISH-positive" AKT1 and AKT2 gene increases (amplification/high-level polysomy) were found exclusively in the cases overexpressing total Akt, Akt1 or Akt2, respectively, AKT3 increase was irrelevant of Akt3 expression.
These genes are often present in published lists of differentially expressed genes and even classifiers, indicating that uncontrolled procedural variables may continue to contribute biologically irrelevant signals to expression profiles.
