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The net iAUC was chosen to minimise biologically irrelevant deviations from the baseline values that would otherwise be taken into consideration by calculating only the positive iAUC.
In a recent study by Reich et al. (2013), both nonspeech and speech stimuli were used in a paradigm where participants responded to the second syllable of a spondee or the duration of a tone, while irrelevant deviations were introduced by changing the first syllable of the spondee or its pitch, or the frequency of the tone.
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In other words, subjects' performance was impaired by task-irrelevant deviations.
It will be overpowered if samples are large, hence irrelevant model deviations will become significant, although they might be acceptable from a substantial point of view, which, in turn, might give rise to generally scorn the LRT as such.
The PDR decrement to a repeated standard sound, recovery to a deviant sound, and dishabituation to the re-presentation of the standard were assessed for small and large deviations embedded in irrelevant auditory sequences.
Positive responses were defined as mean plus 3 standard deviations of the irrelevant peptide responses.
For each group of mice the average background spots obtained in the absence of peptide and in the presence of the irrelevant peptide plus one standard deviation of this average was considered as the cut-off for a positive response.
For example looking for MD trajectories with a particular RMSD (root mean square deviation) value would be irrelevant without providing more context about the system and the method used to calculate the value.
In order to do this they have invented between-patient standard deviations that are, in fact, irrelevant to judging the outcome from a cross-over trial.
In order to state with 95% confidence that probe P300s were more positive than irrelevant P300s, the value at 1.65 standard deviations below the mean of this distribution of differences should be greater than zero.
"There are so many deviations from the film, it would be irrelevant," explains the writer, Joel Horwood.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com