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They have viewed the UNFCCC as irrelevant at best ….
For many in Silicon Valley, government is irrelevant at best and obstructionist at worst.
It's also why fretting over the decline in the artistry of wide releases is irrelevant at best, destructive at worst.
Liberals think that anyone who has an opinion that strays from theirs is irrelevant at best and dangerous at worst.
He has instead been more or less irrelevant, at best a handy organiser and conveniently noisy distraction from the real operation at hand.
In Russia, only a very small crowd of journalists and liberal intellectuals may pay attention, but this constituency is irrelevant at best, and is often decried as the "fifth column" or "national traitors".
So what we now have is a Democratic party that has been repudiated at the polls, headed by a Democratic National Committee that has become irrelevant at best, run part-time by a series of insider politicians.
Across Europe there are still around 40,000 twin arrangements but even when less controversial, they're often seen as irrelevant at best, or at worst an expensive perk for local politicians.
Or will the decades of political baggage that Mr. McCain brings as a two-time presidential loser, someone long distrusted by conservatives with a reputation as the ultimate Washington insider, end up being irrelevant at best for Mr. Romney — and detrimental at worst?
After being widely dismissed as dead (or irrelevant at best) only five years ago, PC role-playing games have made a tremendous comeback.
It's irrelevant at best and dangerously misleading at worst.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com