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Furthermore, in Mesp2 null embryos, there was differentiation into dermomyotome and sclerotome and delayed irregular segmentation of the dermomyotome without obvious segmentation in the sclerotome (Fig. 4) (Saga et al., 1997).
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Lfng−/− embryos show irregular and incomplete segmentation of the PSM and perturbed cranial-caudal patterning of somites.
Wormanns et al. [ 22] showed good repeatability of semi-automated volumetric measurements of small lung nodules, but an irregular shape degrades the segmentation process, contributing to larger variability [ 23].
Figure 7b shows the DSC values obtained by the different PET-AS methods tested for the segmentation of the irregular lesion.
The comparison between the segmentation of the irregular lesion modelled with homogeneous uptake and the sphere from the NEMA IEC body phantom (cf. Fig. 6) showed a visible decrease in performance of all segmentation methods.
There was a volume difference of >10% in only 3.7%, mostly due to incomplete segmentation due to irregular shape or margins.
In the case of drusen, pigment epithelial detachments (PED) or irregular RPE shapes we apply a segmentation algorithm that is similar to the one described in [ 17].
When looking carefully to Figure 1, despite the "misdetection" of irregular fibers and artifacts by the automatic segmentation, we can easily see the detection of the myelin sheath background pixels, even to the point of uniting two separate fibers.
Due to the complex and irregular morphology of plants, no generic mesh segmentation algorithm [ 24, 25] is accurate and robust enough to identify the different plant parts (main stem, petioles, leaves).
The most frequent cause of variability was incomplete segmentation performed by the software due to an irregular shape or irregular margins of the nodule.
Furthermore, an intensity variation penalization term is proposed to make sure that the segmentation result is robust to the irregular intensity variation.
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