Whereas Zasp localizes correctly at the Z-band in ΔC3GMS mutants, the Z-band itself is irregular, raising the possibility that the integrin mislocalization observed in ΔC3GMS mutant animals may partially be the result of defective anchorage of actin filaments to the Z bands.
Borders: Benign lesions are usually regular and flush with the skin while melanomas may have irregular and/or raised borders.
Slit-lamp examination of the right eye showed a 12 mm white-yellowish central corneal epithelial defect with irregular and raised edges, along with intense hyperemia of the conjunctiva, photophobia and pain.
Some nodules, due to their confluence tendency and irregular appearance, raise the problem of differential diagnosis with neoplastic disorders [ 10, 34, 35].
The auditor discovered "irregular transactions that raised concerns of fraud," the F.H.A. said.
The seed coat epidermal cell shapes were irregular or polygonal with raised and undulated anticlinal boundaries, and folded or flattened to concave periclinal walls.
Several units, such as Z and M Special Units, were also raised for irregular warfare as were 12 commando companies.
Significance raised with irregular shape (88%), spiculated margin (97%), rim enhancement (98%), fast initial increase (90%), post initial plateau (65%), and intermediate T2 result (82%).
A more irregular texture should raise the suspicion of superinfection or steatonecrosis (Fig. 10b).
The flow of contrast material flow into the diverticulum, together with irregular borders, should raise suspicion of chronic inflammatory or neoplastic changes [2].
