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However, it could be used for other types of methylation data especially when sparsity and irregular coverage is an issue.
Figure 3B shows the irregular coverage pattern in BCL2 from non-mutated controls (black line) compared to that observed for initial mapping of a highly mutated, highly heterogeneous tumor specimen FL-128 (blue circles), in which reduced local coverage correlates with mutational load.
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The irregular sensor coverage causes a false association with a noncorresponding identification when objects move around the boundary of the modeled coverage.
The most decisive factors are the irregular data coverage in the basin area and the possibly deep-rooted and three-dimensional character of the causative processes.
AQS monitors that had < 2 years of data or had irregular temporal coverage (e.g., operated only in the summer) were not used.
In addition, evidence suggests a low capacity of the laboratory network of the Unified Health System in Brazil for identifying intraepithelial lesions, a lack of specialized human resources, failure in the following of positive cases, and irregular screening coverage.
In addition, variable pixel size tomography can reduce the underdetermined problem in an ill-posed inverse problem when the data coverage is irregular or less by adjusting quantitative proportion of pixels with different sizes.
The NPs turn into irregular in shape and their coverage density increases strongly.
However, its taxonomic coverage is highly irregular, with some groups being much more represented than others.
Despite irregular acceptance and overall vaccination coverage below 75%, 10 years of routine immunisation reduced varicella-related deaths from approximately 100, to 26 per year, with the highest reduction (92%) also observed in children aged 1 4 years.
DOI: http://dx.doi.org/10.7554/eLife.00181.010 Another distinctive type of arbor, which we refer to as thick ending (TE), has only 20 80 branch points and exhibits relatively sparse coverage of an irregular area of 300 500 μm in diameter at a depth of ∼20 μm from the skin surface.
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