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Chen et al (2003) examined the optimal timing of PTX treatment and irradiation in relation to the cell cycle, and recommended that radiation be given at least 5 h after PTX administration, because G2/M arrest of a lung cancer cell line was shown to start at 4 h after PTX treatment and to last for 44 h.
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Here we examine the effects of RAF1 protein on the rate of exit from a G2/M block induced by γ-irradiation in relation to intrinsic cellular radiosensitivity in human cell lines expressing wild-type p53 (wtproteinotein as compared to mutant p53 (mutproteinotein.
These results clearly show that the responsive kinetics of the gels can be controlled by adjusting the irradiation temperature in relation to the homogeneity of the nanoscopically crosslinked structure and the microscopic gel network.
These different defects induced by irradiation are discussed in relation to the disorder of microstructure.
Franko et al [ 23] pointed out the pathomorphological effects in irradiated lung in relation to the lung function; fibrosis was first observed 8 weeks post-irradiation at 10.3 Gy and the number of fibrotic lesions had increased 10- fold by 14 weeks.
Biological effects of low-dose irradiation are of great interest in relation to the induction of cancer and genetic abnormalities.
Investigation of the early change in bladder reservoir function in the animals treated with 20 Gy alone or a combination of 20 Gy plus cis-DDP at various intervals in relation to irradiation demonstrated a significant increase in response when cis-DDP was administered 24 h and 15 min before and 4 h, 72 h and 336 h after 20 Gy (P less than 0.05).
We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring.
As shown in Figure 5, the percentage of cells (measured in relation to pre-irradiation) recovered from thymus rapidly decreased in the first 3 days after irradiation, with minimum values of 1 2%.
No difference in survival was seen in relation to age, previous irradiation, serum HCG or LDH; bulk disease however, was an adverse prognostic factor.
In these cells the increase observed in ROS production in relation to the non-irradiated cells was significant, even for the lower irradiation dose used (2 Gy).
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