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As would be expected in anaemia of chronic disease, laboratory indices indicated suppression of endogenous EPO and evidence of impaired iron utilisation.
Iron utilisation appears defective, as indicated by typically low serum iron in the presence of adequate or elevated iron stores (Lee, 1983; Means and Kranz, 1992; Moliterno and Spivak, 1996).
IRE structures have been detected in several mRNAs encoding proteins related to iron utilisation (eALAS; mitochondrial aconitase, approved gene symbol ACO2; Drosophila succinate dehydrogenase, gene symbol SDHB), uptake [divalent metal transporter 1 (DMT1), official symbol SLC11A2] and release (ferroportin, gene symbol SLC40A1) (Refs 2, 3, 4, 5, 6, 7, 8).
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To achieve this, the control of genes encoding proteins involved in iron uptake, utilisation, storage and export must be tightly coordinated.
Organic matter plays an important role in ASS, as energy source for sulfate reducing bacteria during submergence and by stimulating competition for oxygen between oxidation of iron sulfide and utilisation by decomposers during dry periods.
Over the past decade it has been shown that other genes involved in iron uptake, release and utilisation are also controlled by the IRE IRP regulatory network (see below).
The first is the continuous re-utilisation of iron from catabolised erythrocytes in the body.
The reduced abundance of siderophore-associated proteins in blood isolates may represent a switch towards utilisation of alternative iron sources in blood, including haemin and ferritin, which Bcc use very effectively49.
Furthermore, over this time period, there have been improvements in several indicators relating to women's nutrition and health, such increasing BMI, increasing utilisation of antenatal care and iron and folic acid supplementation, increasing use of contraception, as well as increased age at marriage and decreased total fertility rate.
Maps on land-cover distribution in the late 17th century was used as a model for the utilisation of the landscape during the Iron Age.
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