Sentence examples for iron disorder from inspiring English sources
We acknowledge the observational character of our study, which was not designed to investigate either the cause of abnormal iron status or the mechanisms linking iron disorder to poor outcomes.
Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders.
Hepcidin is the main regulator of iron metabolism and a pathogenic factor in iron disorders.
Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics for iron disorders.
The mouse is a valuable model for understanding human iron disorders.
After examining the analytical characteristics of this assay, which were found satisfactory, we proceeded in determining the clinical value of it by measuring hepcidin levels in patients with several iron disorders.
Molecular understanding of these processes has provided important insights into the pathophysiology of human iron disorders.
Modulating hepcidin expression by targeting the BMP-SMAD signaling pathway in hepatocytes may be an effective modality for treating iron disorders, particularly those associated with a relative hepcidin deficiency or excess.
Soon after its identification in 2000, it was realized that the liver-expressed peptide hepcidin plays a central role in the systemic regulation of iron metabolism; its imbalance or aberrant expression was found to be at the centre of many iron disorders.
Recently, Ganz et al. reported that serum hepcidin levels were increased in patients who had inflammation and an elevated serum CRP level, multiple myeloma, or chronic kidney disease, indicating that hepcidin is influenced by physiologic, pathologic, and genetic factors, and that it provides useful information about the etiology of iron disorders [ 29].
