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The presence of secondary or tertiary amines on guanidine limits or hinders the formation of iron complexes and, as a result, the produced materials are not very active.
Conversely, the presence of primary amines promotes the formation of iron complexes, and, during the pyrolysis, of iron nanoparticles and ordered graphitic planes, making the final material very active for ORR.
Experimental evidence for a nickel transport function across the outer membrane by a protein from this group has been provided [43]; this clearly extends the substrate spectrum of TonB-energized transport, previously thought to be restricted to iron complexes and cobalamin compounds [44].
Also present in SOPE are ABC transporters for polyamines and several amino acids, such as glutamate, aspartate, and d-methionine as well as transporters for sulfate, iron complexes, and zinc.
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Interaction between iron complex and H2O2 in the slurry is the main factor governing the chemical mode of material removal, oxidation potencies and kinetics.
Six of these TBDPs (FpvU to FpvZ) function as ferric-pyoverdine receptors (FPVs) that facilitate the uptake of specific pyoverdine-iron complexes and enable this bacterium to use not only its native pyoverdine, but also heterologous pyoverdines from other strains.
According to the KEGG pathway map, the strain may be able to transport molybdate, iron complexes, lipopolysaccharides and lipoproteins.
It can be concluded that barbituric acid moiety is essential for the protection activity against DNA damage induced by bleomycin-iron complex, and thiobarbituric acid ring is also required for the activity.
Considering that the DOX toxicity is based on free radical production, it can be concluded that the protective role of fullerenol relies on its high antioxidative potential, acting as a free radical scavenger and/or by removing free iron ions through the formation of the fullerenol-iron complex and preventing the Fenton/Haber-Weiss reaction [ 44].
From the obtained results (Table 1), it can be concluded that pyrimidine moiety is essential for the protection activity against DNA damage induced by bleomycin-iron complex, and pyrimidine ring is also required for the activity and an unsubstituted phenyl ring exhibited better activity than those substituted derivatives.
In the presence of Fe2+, it is expected that alanine and acetate form iron complexes ([CH3NH2CHCOOFe]+ and [CH3COO-Fe]+), which then can interact with surface sulfur sites.[42] It should be kept in mind that the speciation in experiments with iron is pH dependent.
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