Sentence examples similar to ips 1 from inspiring English sources

Furthermore, EGCG does not inhibit IPS-1 or an event downstream of IPS-1 (Table 1).

EGCG was unable to inhibit ligand-independent IPS-1-activated reporters, demonstrating that EGCG did not affect the signaling pathway downstream of IPS-1 activation (Table 1).

Finally, constitutive signal transduction by over-expressed IPS-1 was not affected by EGCG, indicating that EGCG does not act downstream of the IPS-1 in this signaling pathway (Table 1).

Yeast two-hybrid studies demonstrated that DDX3 binds IPS-1, and both are constitutively present prior to infection (Fig. 1).

The constitutive expression and up-regulation of EsMDA5 and the IPS-1 genes in different tissues indicate that EsMDA5 may play an important role in sensing viral PAMPs in conjunction with IPS-1.

HCV polyU/UC promoted IPS-1-mediated IFN-beta induction, and this was further enhanced by forced expression of DDX3/IPS-1 (Fig. 2A).

DDX3 primarily is an accelerating factor for antiviral response through IPS-1-binding.

Peroxisomes serve as signaling platforms for recruiting IPS-1 with a different signalosome than mitochondria [43].

Indeed, there are a number of mitochondria-specific molecules which assemble with IPS-1 [45].

Interestingly, while RLH signaling totally depends on IPS-1, contribution of IPS-1 to the cytosolic DNA sensing signaling has been controversial; one group reported dispensability of IPS-1 whereas the other reported partial involvement of IPS-1 in the cytosolic DNA sensing signaling [35], [36].

TICAM-1 (TRIF) −/− and IPS-1 −/− mice were established in our laboratory [4], [33].