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Lactoferrin is a member of transferrin family and binds two ferric ions with high affinity (Torti and Torti, 2013; Ward et al., 2003).
To obtain a selective and sensitive layer for calcium sensing, the SiNWs are modified with a biologically relevant amino acid phosphotyrosine (p-Tyr), which is able to complex calcium ions with high affinity.
PrPC binds copper (II) ions with high affinity.
The C-terminal domain of HMA2 has been shown to bind three Zn2+ ions with high affinity [19].
Cys and His residues have been identified as metal-binding residues in the C-terminus of AtHMA2, binding three Zn2+ ions with high affinity (Kd ∼16 nM).
Annexin V binds in the presence of calcium ions with high affinity to the negatively charged phosphatidylserine [ 40].
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Transferrins are glycoproteins that bind iron ion with high affinity.
Intriguingly, the lack of specificity was demonstrated because the D-allo-ShK was still able to block several K+ ion channels with high affinity [40,42].
For example, members of 3FTx family exhibit a wide variety of specific pharmacologic effects by targeting various receptors and ion channels with high affinity and specificity.
ShK blocks the T cell specific Kv1.3 channel with an IC50 of 16 pM, as well as the Kv1.1 channel and several other ion channels with high affinities.
In particular, the Cu2+ ion binds to Aβ with high affinity and has been shown to potentiate Aβ neurotoxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com