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Activation of GPCRs mostly results in a slight rotation and upward movement of TM3, a rotation of TM6 and inward movements of TM1, TM5 and TM7.
The movements during activation of the transmembrane helices at their extracellular ends involve (Fig. 2a) inward movements of TM1and towardsards the core of the helix bundle, upward movements of TM3 and TM6 and a small lateral movement of TM6.
The movements of the intracellular ends of the transmembrane helices (Fig. 2b) involve outward movements of TM1 and TM6 away from the core of the helix bundle, inward movements of TM5 and TM7, a downward movement of TM3 and a rotation of TM6 (Fig. 2c).
These inward movements always crossed the body midline.
This movement triggers concomitant inward movements of the interacting Glu49-His50-Pro51 loop of 0.45 Å on LecA.
A significant interaction between response hand and movement direction (F 1, 15) = 52.9, p < .001) replicated the finding of Experiment 1 that congruent outward movements were faster than incongruent inward movements (690 and 776 ms, respectively).
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This inward movement seems to have proved corrosive.
The ITB's primary function is to control and decelerate the adduction (inward movement) of the thigh on heel strike, as during running.
Financial bother led to a summer of significant departures from Gigg Lane and even though the arrival of Neil Danns represented at least some encouraging inward movement, they look too weak to get close to last season's 16th-place finish.
The main blow, it was planned, should be delivered by A.E. Evert's central group of armies, assisted by an inward movement of A.N. Kuropatkin's army in the northern sector of the front.
Colours at the negative end represented regions which had inward movement or concavity with respect to the reference surface.
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