This inward movement seems to have proved corrosive.
Despite this similarity, bosentan sterically prevents the inward movement of transmembrane helix 6 (TM6), and thus exerts its antagonistic activity.
Accordingly, Arg3436.55 is attracted toward the sulfonamide, and hence bosentan induces only a slight inward movement of TM6 (Fig. 4c,e).
The radially inward movement of bubbles from low to high axial velocity (from column wall to center, i.e., CL<0) was observed at most of the measurement locations.
The ITB's primary function is to control and decelerate the adduction (inward movement) of the thigh on heel strike, as during running.
Financial bother led to a summer of significant departures from Gigg Lane and even though the arrival of Neil Danns represented at least some encouraging inward movement, they look too weak to get close to last season's 16th-place finish.
In addition, the 2-methoxyphenoxy group of bosentan protrudes farther toward TM6 compared with the Trp21 side chain of ET-1, thereby sterically preventing the inward movement of TM6 (Fig. 4c,f).
Gastrulation consists of the inward movement, or invagination, of the cells of one side of the blastula until they are juxtaposed to the opposite side; thus the spherical embryo is converted into a double-walled cup, or gastrula.
The inward movement of one side of the blastula's cells has contracted or eliminated the blastocoel, which was the cavity of the blastula, but a new cavity is formed in the hollow of the cup.
Furthermore, bosentan does not induce any inward movement of TM7 because it only poorly interacts with TM7, as compared with ET-1 (Figs. 3b and 4e, and Supplementary Fig. 7d,e).
The main blow, it was planned, should be delivered by A.E. Evert's central group of armies, assisted by an inward movement of A.N. Kuropatkin's army in the northern sector of the front.
