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A consistent phenotype involving abnormalities of the midbrain-hindbrain boundary (MHB) became apparent at 24 hpf (Figure 3A, c and e).
70 Those with MI also share a genetic background with AD, involving abnormalities in cholesterol metabolism and an upregulation in inflammation.
WBS is a multi-system disorder involving abnormalities in growth, development, internal organs, connective tissue, bone formation as well as a characteristic cognitive-behavioural profile (Bellugi et al, 2001).
Identification of genetic associations of IS, a rapidly developing area, suggests IS is a genetically heterogeneous condition involving abnormalities in key developmental pathways in the ventral forebrain and synaptic functional pathways [ 18].
We hypothesized that the changes in white matter FA in TRD are similar to general affective disorders involving abnormalities of the cortical-limbic or cortical-subcortical circuits, as well as other important areas related to emotional regulation.
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However, the most likely explanation for abnormal HR response involves abnormalities in autonomic nervous system modulation [ 17].
Fracture risk not only involves abnormalities of bone mass and architecture, but also factors that affect the incidence of falls.
In this review we set up the background for this hypothesis by integrating a large body of disparate indirect evidence that dystonia may involve abnormalities in synaptic plasticity in the striatum.
Because NF-κB may play roles in a range of diseases that involve abnormalities in regulation of cell death, pharmacological and genetic manipulations of NF-κB signaling are being developed in order to either enhance (e.g. cancer) or prevent (e.g. Alzheimer's disease) apoptosis.
It has been suggested that child neglect involves abnormalities in parental appetitive motivation (lack of hedonic reward from children) rather than an inability to perform a particular parental behavior [10].
The suppressor pathway, observed in >80% of CRC cases, involves abnormalities of the APC/wingless signalling pathway and is characterized by frequent somatic mutations of oncogenes and loss of heterozygosity of tumor suppressor genes, chromosomal instability, and microsatellite stable (MSS) tumors.
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