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The stabilization of the 7amG-modified OL-1b duplex not only involves the modified X C base pair but also extends in the 5′-direction relative to X, to involve the A T and G C base pairs.
Their ordeal is by no means over yet because while Bobbie has found what she hopes will be a workable therapy plan for Gaberila -- it involves the modified Atkins diet with minimal medication and should allow Gaberila to eventually lead a normal life -- their insurance company, surprise, won't cover most of the costs which will exceed $100,000 over the next year.
Maximum-likelihood (ML) estimation is more complicated since the likelihood involves the modified Bessel function.
The fact that the enthalpic stabilization of the modified OL-1b duplex not only involves the modified X C base pair but also extends in the 5′-direction to involve the A T and G C base pairs provides a new example of cation-mediated sequence-specific modulation of DNA stability.
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The underlying mechanism of MWT is complex involving the modified crystallization of scale-forming components and modified dispersion stability.
These results suggest that the intracerebroventricular enzyme replacement therapy involving the modified HexB should be more effective for Tay-Sachs and Sandhoff than that utilizing the HexA, especially as a low-antigenic enzyme replacement therapy for Tay-Sachs patients who have endogenous WT HexB.
Three-duplicate ACKs involve the modified LD and DCR.
Finally, we discuss strong convergence of the iteration scheme involving the modified viscosity approximation method [10] defined as follows: x 1 ∈ C and x n + 1 = α n f ( x n ) + β n x n + γ n B n x n, ∀ n ≥ 1, (1.3).
The pattern of chemical shift perturbations indicated that the lesion introduced a localized structural perturbation involving the modified base pair and its 3′- and 5′-neighbor base pairs.
When placed in 5′-d CGCXCGGCATG -3′ at pH 5′-d CGCXCGGCATG -3′ localized structural perturbation involving the modified base pair and its 3′-neighbor.
Given the position of the C7 5′-PO4– in the S-turn, the destabilizing effect of the C7-Rp phosphorothioate modification could be due to a perturbed divalent metal coordination involving the modified atom.
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