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As several studies have made clear, it involves substantial costs ('cost discovery') (Hausmann and Rodrik 2003).
In many countries registration of enterprises is extremely tortuous and time consuming and often involves substantial costs, including bribes.
Administration by infusion using a central vein catheter involves substantial costs, whereas replacing it with oral therapy combined with drugs administered intravenously results in savings in health resources for the hospital which translates into a reduction in the time that the medical staff spend administering therapy and more efficient use of the day hospital.
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Such restoration work involves substantial cost, and it is important to know if the benefits generated from "living streams" are greater than restoration costs.
However, PET imaging is not suited to screening test of general population because PET examination involves substantial cost.
It may first consider retrofitting the buildings of the most vulnerable construction type, for example, the miscellaneous and brick-wood buildings; then retrofitting composite masonry, which will involve substantial costs, can be considered.
Fourth, the investigation and clinical care of case-patients involved substantial costs to the health care system.
However, extra-group matings also involve substantial costs as they occur during violent encounters that sometimes result in injury and death.
While non-contract physicians to some extent enlarge the consumer choice for publicly funded outpatient care, private treatments usually also involve substantial cost sharing.
However, the traditional cost-effectiveness analysis of diagnostic tests has involved collecting additional data on alternative treatments that could involve substantial cost and sometimes might be difficult to collect (46, 47).
From a practical perspective this requires a considerable time commitment from patients and involves substantial treatment costs that would not necessarily be sustainable in everyday practice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com