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During the optimization metamodeling is used, which involves sensitivity analysis, design of experiments and regression analysis.
The first one is mediated by IP3R and/or RYR activation and involves sensitivity to [Ca2+i levels.
As motivational salience involves sensitivity to both reinforcers, motivational salience acquired via pseudoconditioning might not explain well the non-reward coding dopamine activations.
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Boaden wrote: "It seems to me this basically comes down to two boys fighting for control of a complex and complicated story which should have involved sensitivity, as well as rigour, proper evidence, proper interviews, and failing to manage the most basic elements, what was the story about.
They involve sensitivity functions.
An optimization scheme involving sensitivity analysis is applied to obtain the optimal values of m and k.
Two numerical examples involving sensitivity analysis of vibro-acoustic systems illustrate the feasibility and effectiveness of the proposed interval-based method.
Alternative screening scenarios were described using five attributes namely: preparation involved, sensitivity, specificity, complication rate and testing frequency.
Since it is possible that a range of parameter values could provide similar unperturbed state values, another area of future investigation would involve sensitivity analysis of the model.
Second, due to the nature of the study which involved sensitivity matter and self-reporting, information bias could be introduced which may have affected reliability of the results.
However, when we designed the questionnaire we felt that anyone supporting a screening program has to be familiar with the health problem targeted by the program, the features of the test involved (sensitivity and specificity) and the programme expected benefits.
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