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Assuming that the inhibition observed involves reaction with the Cys112 residue, then the ligands must be situated in the vicinity of the catalytic triad.
A second important metabolic pathway for MMA involves reaction with tissue nucleophiles via Michael addition on the electrophilic C of the a,β-unsaturated carboxyl group (Freidig et al., 1999; Greim et al., 1995; McCarthy et al., 1994).
It is therefore likely that the efficient binding of labeled GSH to BCNU treated DNA involves reaction with other more abundant BCNU derived lesion(s) that are not involved in G-C ethane cross-link formation.
Similar(57)
The latter involves reactions with the water layer and not with surface sites.
As we see in Figure 1, the full network involves reactions with more than two reactants or products.
The carboxylic acid of complex 3 shows significant influence on the second reduction due to the acid group involving reaction with the reduced species.
For reactive distillation columns involving reactions with negligibly or no thermal effect, process intensification can be performed with an exclusive consideration of internal mass integration.
For reactive distillation columns involving reactions with moderately thermal effect, process intensification must be conducted with a careful trade-off between internal mass and energy integration.
Intradomain reactions inside the LXD involved reactions with dangling chains, which would not affect the average mesh size of the domain significantly.
For reactive distillation columns involving reactions with highly thermal effect, process intensification can be achieved with an exclusive consideration of internal energy integration between the reaction operation and separation operation involved.
The thermodynamic efficiency of a reactive distillation column involving reactions with a highly thermal effect could sometimes be improved substantially through seeking further internal heat integration between the reaction operation and separation operation.
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