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The first involves perturbation of component modal properties which can be related to perturbations in the modes of the assembled structure and hence to the energies and CLFs.
The subfertility associated with uterine infection involves perturbation of the hypothalamus, pituitary and ovary, in addition to the direct effects on the uterus, and appears to persist even after clinical resolution of the disease.
These results identify a new and highly potent curcumin derivative and demonstrate that in cells where curcumin and RL197 induce ROS, an important underlying mechanism of action involves perturbation of miR-ZBTB10/ZBTB4, resulting in the induction of these repressors which downregulate Sp transcription factors and Sp-regulated genes.
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Importantly, dysregulation of Cdk5 has been linked to Alzheimer's disease, which involves perturbations in synaptic functions and memory formation.
One scenario involves perturbations of Sedna's orbit by a hypothetical planetary-sized body in the inner Oort cloud.
This is consistent with an ensemble-based explanation of allostery that involves perturbations to the population of energetic states around the native state, and not the existence of intricate pairwise-coupling pathways or sequential conformational changes [40].
The mechanism by which PhoQ is activated by acidic pH appears to be distinct from CAMP and involves perturbations to a network of residues surrounding H157 within the α/β-core of the PD (Prost et al., 2007).
In particular, in simulations of the receptor with the β-arrestin-biased agonist N-cyclopentylbutanepherine, we observe a different pattern of motions in helix 7 when compared to simulations with the G protein-biased agonist salbutamol that involves perturbations of the network of interactions within the NPxxY motif.
Chemoprevention may involve perturbation of a variety of steps in tumour initiation, promotion and progression.
Disruption to mitochondrial transport was directional involving perturbation to anterograde but not retrograde movement.
These results suggested a plausible mechanism for the allosteric regulation of MtIPMS involving perturbation of the helix by l-leucine binding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com