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Since the Reader shutdown announcement, the company said it's now making plans to continue development, but this involves major changes on its part.
Senescence is a complex phenotype that involves major changes in cellular function and structure.
Minimally disruptive medicine involves major changes in thinking about how 'whole systems' function and what they do.
The first of the many steps leading to metastasis – the acquisition of local invasiveness involves major changes in the phenotype of cancer cells within the primary tumour.
This process involves major changes in chromatin structure, which, for osmoresponsive genes, require the presence of Hog1 (Mas et al. 2009).
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Despite the discrepancies, a fix shouldn't involve major changes.
Almost certainly the process will involve major changes to the hospital's leadership, which was strongly censured by the CQC.
Sometimes this involved major changes to the user interface – in a car analogy, the engine stayed the same but the dashboard and controls got a makeover.
"The next phase of improvements will be challenging for Foxconn because they involve major changes in the working environment that will inevitably cause uncertainty and anxiety among workers.
He has done independent advance polling for the past three Mongolian national elections, two of which involved major changes of political power, and, in each case, his results predicted the winner to within fewer than 2.8 percentage points.
The Conservatives came up with a plan which could involve major changes in the way the internet is regulated.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com