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Its catalytic activity, which involves its function in muscle is elaborately regulated.
In contrast, activation of MAPK/JNK with anisomycin maintained MTOR activation and prevented autophagy induction, further support that the role of MAPK/JNK signaling in development involves its function in a pathway that prevents the induction of autophagy.
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Taken together these findings suggest that KDM1 activities are highly gene-specific and likely to involve its function in a protein complex with HDAC and other proteins.
The ICD-8 and -9 diagnostic prototypes, valid until 1992, described schizophrenia as a "fundamental disturbance of the personality, which involves its most basic functions, those that give the normal person his feeling of individuality, uniqueness, and self-direction" (emphasis added).
A condition involving its isoperimetric function is also provided.
The main reason is that, despite its simplicity, the network representation can disclose some relevant features of the system at large, involving its structure, its function, as well as the interplay between structure and function.
Control of epidermal proliferation and differentiation by IKKα does not involve its protein kinase function and is completely independent from NF-κB activation (Hu et al, 2001).
On the basis of available literature, however, it is likely that the bulk of the DDX3X molecular functions involve its RNA binding and helicase function.
Therefore, the proteasome-related activity of BRCA1 may indirectly involve its DNA repair-associated function.
Activation of p53 function involved its increased transcriptional activation, DNA-binding ability, increased expression of p53 target genes associated with cell cycle progression and apoptosis.
We also mapped the ligand-binding residues on the Alba3 surface to analyze its druggability and performed mutational analyses in Alba3 using alanine scanning to identify residues involved in its function and structural stability.
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