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The PocketDepth algorithm was later combined with LIGSITEcsc, which uses Connolly's surface (42) to identify surface solvent surface events that involves grooves and then detects binding sites in a given protein by mapping the degree of conservation of the residues in the selected surface.
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This introductory study therefore involves transverse grooves only.
Thus, methylation of DNA in the major groove at deoxyuridine or deoxycytidine residues diminishes both DNA binding and cleavage, the latter of which involves minor groove chemistry.
The process involves scanning the grooves of the Dictaphone belt electronically to create a digital image of the sound patterns.
The data indicate that both ligands interact with CT-DNA via a combined mode of action involving both groove binding and non-classical intercalation, while in the case of the complexes covalent bond formation takes place as well.
The fabrication process involves etching a groove on the surface of a silicon die, molding the polymer into this groove, and then releasing it.
The preparation of the samples involved making longitudinally grooves on the buccal and lingual surfaces of the root with a diamond bur.
A key event in the regulation of apoptosis is the heterodimerization between anti-apoptotic and pro-apoptotic family members, which involves a conserved surface-exposed groove on the anti-apoptotic proteins.
If the contact involves a base in the major/minor groove, it is annotated as a major/minor groove contact.
In keeping with this, there is evidence that binding of cholesterol and other lipids by membrane proteins often occurs in grooves between helices and involves conserved spatial motifs.
Now that we've covered what NXT is and how it's involved in the Groove lets move onto the functionality of the backpack itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com