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Another difference between the two drugs involves dose frequency.
The toxicologic approach involves dose selection based on the maximum tolerated dose, which can be described as "top-down dose selection," whereas the physiologic approach used by Nagel et al. (1997) can be described as "bottom-up dose selection" (Welshons et al. 2003).
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The method, used only in the first trimester, involves doses of two drugs, mifepristone (RU-486) and misoprostol, over a 48-hour period.
Anthracyclines are a well known example of cardiotoxicity; the pathophysiological mechanism is complex but involves dose-related myocardial cell death during cancer treatment and possibly an impairment of reparatory and homoeostatic mechanisms after the exposure to chemotherapy [30,31].
Study design involved dose escalation (four patients/cohort) using a modified Fibonacci schema starting at 0.7 mg DNA administered via single intratumoral injection.
Besides, studies involving dose depending effects are rare [ 16, 19].
Therapeutic switching is also likely to involve dose titration of the new drug.
Stage 1 of the study involved dose escalation in cohorts of three to six patients.
Types of labelling error are shown in table 1; these most commonly involved dose instructions and additional warning labels.
All experiments on mutant strains were conducted at least twice, while those involving dose response curves represent the combined results from two (LH846) or three (PF670462) experiments.
On may argue that there is no benefit of further dose escalation after resection due to failure of trials involving dose escalation or additional radiosurgery to the tumor bed [ 38].
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