Cross-presentation involves different steps; i) endocytosis of antigens, ii) their degradation and processing of the generated peptides onto MHC class I molecules, and iii) the expression of costimulatory molecules on APC surface.
Model development is a key task in systems biology, and involves different steps, such as model calibration, experimental design and model refinement which usually take place in an iterative way (see reviews in [ 1- 5]).
The purification method involved different steps: differential centrifugation, precipitation of nonmicrovillus membranes with magnesium ions, and a sucrose gradient step.
An individual miRNA can regulate dozens of distinct mRNAs, involving different steps for regulating the metastasis of breast cancer cells [5], indicating the important role and multiple functions of miRNAs in control of tumor progression.
Although in the past decade a variety of studies have focused on quality indicators for palliative care, the methods found in the literature by which indicators were developed were not always clearly presented and not always seemed to follow a systematic approach involving different steps of the development process [ 10- 26].
Indeed, the complex transformation process of stem/progenitor cells into CSCs may involve different steps and it may occur in parallel with a deregulated microenvironment, associated with telomere attrition, inactivation of tumour suppressor genes and upregulation of oncogenes together with genomic and epigenetic instability.
This multi-step carcinogenesis involves different stages, such as hyperplastic lesions, mild/moderate/severe dysplastic lesions, and in situ carcinomas.
Following a signal from the cumulative count of conforming (CCC) control chart, the performance of the proposed monotonic change-point estimator is next evaluated by comparing its performances to the ones designed for step-changes and linear-trend disturbances through extensive simulation experiments involving different single step-changes, linear-trend disturbances, and multiple-step changes.
Acute management of these patients in the emergency department involves several different steps, but most importantly, the diagnosis must be made quickly, and general surgeons should be involved immediately upon making the diagnosis of a perforated ulcer.
Metabolism of dietary sugars (glycolysis) involves several different steps of phosphorylation by distinct kinases.
Design of diagnosis systems is a complex task that involves many different steps.
