Alternatively, the genesis of elastofibroma is thought to involve an overproduction of the collagenous connective tissue with a degeneration of the collagen fibres and an overproduction of immature elastic tissue, derived from fibroblasts, alternating with deposition of hyperplastic fat [2, 8, 10].
When regeneration does not fully occur, reparative processes involving an overproduction of stromal components ensure the continuity of tissue at the expense of its normal structure and function, resulting in a "reparative disorder".
Experimental and clinical data have demonstrated that, between the many factors involved, an overproduction of nitric oxide and peroxynitrite leading to the stimulation of vascular potassium channels is responsible for vascular hyporeactivity [ 6].
CML involves a massive overproduction of white blood cells that kills several thousand men and women in the UK each year.
But, he explains, Alzheimer's involves the overproduction of proteins that form plaque in the brain that destroys neurons.
The action of many cytostatic drugs involves the overproduction of reactive oxygen species, which together with inadequate antioxidant protection can lead to oxidative stress and this has been implicated in the etiology of various diseases.
The possible mechanisms implicated in the pathophysiology of GV include an overproduction of reactive oxygen species through the same four pathways involved in the tissue-damaging effects of hyperglycemia (28).
Thyroid hormone has been shown to be involved in demineralization of bone in eels (Sbaihi et al., 2007), and an overproduction of the same hormone in humans can induce bone loss and osteoporosis.
