Sentence examples for involves a prolonged from inspiring English sources

In 2013, Naviaux spelled out his hypothesis that autism involves a prolonged, heightened cell danger response, disrupting pathways within and between neurons and contributing to the symptoms of the disorder.

Fluorouracil is most active and least toxic when delivered using an infusional schedule (Meta-analysis Group In Cancer 1998) but such treatment either involves a prolonged inpatient stay or the placement of a central line with its attendant risks and inconvenience.

It invariably involves a prolonged slump with high unemployment.

This complication involves a prolonged period of functional limitation and delayed rehabilitation, and can require surgery to reactivate and finalize the bone repair process.

We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas the EPR effect of nanoparticles involves a prolonged retention time days to weeks.

In truth the successful treatment for sex addiction involves a prolonged process, and his forty five days as an in-patient is a mere drop in the bucket.

However, PPI therapy involves an indefinitely prolonged or lifetime daily drug administration, which is associated with significant adverse effects [ 6].

In this approach, several steps are involved: 1) a prolonged periodate oxidation is performed to convert the O-GlcNAc group to its dialdehyde derivative, 2) hydrazide resin is used to capture the oxidized O-GlcNAc peptides, and 3) after proteolytic digestion, the resulting modified peptides are released by hydroxylamine.

His findings in this area have proved disquieting -- and not just because one of the key experiments involved a deliberately prolonged colonoscopy.

Aortic valve operation and ascending aorta replacement (AV AA) typically involves hypothermia, prolonged cardiopulmonary bypass (CPB), and large graft anastomoses, and is associated with an increased risk of intra- and postoperative blood loss and high transfusion rates.

Particularly notable is the marked dissociation between basal and stress-induced HPA activity, in that while basal corticosterone levels are highly suppressed, the response to the relatively brief stimulus of 10 minutes noise stress involves highly prolonged HPA activation (significant elevation for >80 min).