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The proximity of 5'UTR introns to the translation start site is consistent with a role that involves a function in translation, given the simple model of translation we are using.
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Thus, analogous to observations made for Elongator in S. cerevisiae, cytoplasmic signals exhibited by Arabidopsis ELP reporter proteins are in agreement with a role of Elongator outside the nucleus and could involve a function in tRNA maturation (Huang et al., 2005; Rahl et al., 2005).
Commonly used time domain equalizer (TEQ) design methods have been recently unified as an optimization problem involving an objective function in the form of a Rayleigh quotient.
The aging process involves a decline in immune functioning that renders elderly people more vulnerable to disease.
The authors estimated that ~5% of the cancer-relevant mutation involves a change in the protein function rather than standard loss and gain of function mechanism events.
The first type involves a radical shift in biochemical function or expression pattern, giving rise to a new function at high levels of organization [ 37, 38].
In contrast, activation of MAPK/JNK with anisomycin maintained MTOR activation and prevented autophagy induction, further support that the role of MAPK/JNK signaling in development involves its function in a pathway that prevents the induction of autophagy.
The natural course of the disease involves a progressive decline in lung function and exercise capacity, with a simultaneous increase in breathlessness, coughing, wheezing and sputum production [ 1].
The algorithm presented in this work involves a different cost function which is quadratic in the parameters.
Ageing is a complex process that involves a progressive decline in physiological functions of an organism, eventually causing disease and death [ 172].
Taken together these findings suggest that KDM1 activities are highly gene-specific and likely to involve its function in a protein complex with HDAC and other proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com