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For OOI, the frequencies of segmental/multiple proximal bile duct stricture, retroperitoneal fibrosis, symmetrically enlarged salivary/lachrymal glands and radiological evidence of renal involvement were evaluated.
Biomarkers affecting prognosis (histology, tumor size and nodal involvement) were evaluated among those already using digoxin at breast cancer diagnosis, adjusted for age, calendar year and protocol.
31– 34 In a recent trial conducted by Zavagno et al., 431 patients who underwent re-excision due to margin involvement were evaluated from a total of 1,520 patients who underwent BCT.
Clinical details pertaining to major internal organ involvement for lung fibrosis, pulmonary arterial hypertension, renal crisis and significant gastrointestinal (GI) involvement were evaluated using consensus definitions as outlined in previously published studies [ 14].
The International Prognostic Index (IPI: stage, ECOG performance status, serum LDH, stage, extranodal sites) and the Korean Prognostic Index for NK/T-cell lymphoma with nasal disease (KPI: serum LDH level, B symptoms, stage, regional lymph nodes involvement) were evaluated as previously described [ 12, 28].
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In the present study, the association of the serum levels of IL-8, IL-6, C reactive protein (CRP) and rheumatoid factor (RF) with long term pulmonary involvement was evaluated.
Cardiac involvement was evaluated by electrocardiography, echocardiography and physical examination.
Pulmonary involvement was evaluated by lung segments according the Warrick score [ 16].
BVAS and organ involvement was evaluated before CYC induction and before the first RTX treatment.
Clinical skin involvement was evaluated using the modified Rodnan skin score.
Lymphnode involvement was evaluated according to a 5 point scale with a patient- and a field-based analysis.
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