Exact(4)
On the other hand, local involvement of vessels and surrounding organs is still a diagnostic problem.
Our findings, indicating microvascular changes antedating development of autonomic neuropathy, are consistent with earlier pathological involvement of vessels than nerves, and/or an ascending neuropathic process [ 31].
Although the pathogenetic mechanisms and clinical scenarios differ, the diseases share the inflammatory involvement of vessels as the primary event in the disease natural history and the associated multiorgan systemic involvement.
Histologically, the disease progresses from minimal involvement of vessels, with only collections of lymphocytes confined to the internal or external elastic lamina or adventitia to a panarteritis with segmental areas of necrosis of the arterial wall and extensive destruction of the elastic laminae, a feature that can be clearly demonstrated with special stains for elastic fibers.
Similar(56)
Involvement of vessel in a tumor that exceeds one-half the circumference of the vessel is highly specific for unresectable tumor, both for arteries and veins.
Within the group of 247 patients presenting clinical-radiological risk factors for BCVI, 20/247 (8.1 %) patients showed the presence of BCVI at MDCT (a total of 24 injured vessels has been found within this group of 20 patients, since four of them showed the involvement of two vessels each), whereas 227/247 (92.9%%) patients did not definitely show the presence of BCVI at MDCT.
Among the 729 patients without clinical-radiological risk factors for BCVI, 12/729 (1.6 %) patients showed the presence of BCVI at MDCT (a total of 18 injured vessels has been found within this group of 12 patients, since six of them presented the contemporary involvement of two vessels each), whereas 717/729 (98.4 %) did not show the presence of BCVI at MDCT.
The activity of tumor growth is determined by its neoangiogenesis and involvement of existing vessels with their subsequent tumor transformation.
In differently graded tumors, we found differently graded involvement of blood vessels in the tumor development, explaining patients' survival.
It is of interest to note that all the aforementioned disorders are mainly characterized by involvement of small vessels in the brain.
The involvement of small vessels is considered to be a relevant factor in the physiopathology of Raynaud's and CREST syndrome [7].
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